A peer-reviewed study published in npj Antimicrobials and Resistance has demonstrated that Ask Eolas, an AI-powered clinical decision support system developed by Eolas Medical, achieved 100% prescribing accuracy in a randomized controlled study conducted by researchers at Imperial College London, with support from the NIHR Northwest London Patient Safety Research Collaboration. The findings have significant implications for combating the U.S. antibiotic crisis, where up to 50% of antibiotics prescribed in hospitals are unnecessary or inappropriate, contributing to over 2.8 million resistant infections and 35,000 deaths annually, according to the CDC.
The study evaluated three tools across progressively complex prescribing scenarios involving 45 clinicians: Hospital PDF Guidelines (47% accuracy), the Eolas App (60%), and Ask Eolas (100%). The improvement was statistically significant (p < 0.001), with an absolute risk reduction of 53% compared to standard PDF guidelines. The number needed to treat (NNT) was 1.9, meaning for every two clinicians using Ask Eolas, one additional prescribing error was prevented. Clinicians using Ask Eolas also reported substantially higher prescribing confidence and lower cognitive workload across all NASA Task Load Index domains.
Ask Eolas allows clinicians to ask questions in natural language and receive answers drawn exclusively from their health system's approved guidelines and protocols, with full source references. This technology improves clinician access and adherence to hospital-developed protocols at the point of care. Eolas Medical is already deployed across leading U.S. health systems including Mass General Brigham, Stanford, and Boston Children’s Hospital, and is expanding antimicrobial stewardship capabilities nationwide. The company recently opened its U.S. headquarters in Cambridge, Massachusetts.
“This study demonstrates how guideline-grounded AI can strengthen antimicrobial stewardship infrastructure while supporting frontline clinicians in high-pressure environments,” said Dr. Declan Kelly, Founder & CEO of Eolas Medical. “With the opening of our U.S. headquarters in Cambridge, Massachusetts, we are firmly committed to making this technology available to health systems across the country, because every clinician deserves real-time access to the best evidence at the point of care.”
Eolas Medical is a healthcare knowledge management platform used by clinical teams across the United States, United Kingdom, and Ireland to improve access to trusted treatment guidance. Ask Eolas uses retrieval-augmented generation to deliver recommendations grounded exclusively in hospital-approved clinical guidelines, enabling transparent, auditable, and institution-aligned prescribing support. The full study is available here. More information about Eolas Medical can be found at www.eolasmedical.com.
